“Many ME-patients suffer from tremendous exhaustion for days after exercise, the so-called post-exertional malaise, or PEM. There were doubts as to whether the large British PACE trial was correct,” said professor of Internal Medicine and Immunology Jan Willem Cohen Tervaert, a couple of weeks ago in the Myth Busters- series of Observant. The professors Trudie Chalder, Michael Sharpe and Peter White, who led this PACE trail on the chronic fatigue syndrome, are convinced that cognitive behaviour therapy and graded exercise therapy “are moderately effective and safe for patients with CFS/ME. To suggest that this is not the case is to propagate a myth”.